普罗亭 普罗亭
普罗亭
普罗亭
普罗亭
普罗亭 普罗亭
项目成果 最新资讯列表 临床试验列表
普罗亭项目成果
浙江普罗亭健康科技有限公司从成立以来，一直紧密追踪科学研究方向和实验技术手段的革新和方向，通过在全国范围内与众多学术机构建立的广泛合作，完成了多项具有国际先进水平的质谱流式相关项目。迄今为止，普罗亭助力合作伙伴发表SCI文章125余篇，影响因子总计1600分以上，平均影响因子15+分，其中约50%的文章影响因子大于10分，这些文章的发表为生命科学和精准医学发展带来了重要的推进作用。
  • 合作单位
    发表文章
    发表期刊
    IF
    发表时间
  • 北京协和医院
    PD-1 and TIGIT coexpressing CD8 + CD103 + tissue-resident memory cells in endometrial cancer as potential targets for immunotherapy
    International Immunopharmacology
    5.60
    2023-12
  • 福建医科大学附属协和医院
    Correction to: A modified immune cell infiltration score achieves ideal stratification for CD8+ T cell efficacy and immunotherapy benefit in hepatocellular carcinoma
    Cancer Immunol Immunother.
    5.80
    2023-12
  • 福建医科大学附属协和医院
    TGF-β-p-STAT1-LAIR2 axis has a "self-rescue" role for exhausted CD8+ T cells in hepatocellular carcinoma
    Cell Oncol (Dordr).
    6.60
    2023-12
  • 福建医科大学附属协和医院
    SUMOylation inhibitors activate anti-tumor immunity by reshaping the immune microenvironment in a preclinical model of hepatocellular carcinoma
    Cell Oncol (Dordr).
    6.60
    2023-12
  • 浙江大学
    Downregulation of N4-acetylcytidine modification in myeloid cells attenuates immunotherapy and exacerbates hepatocellular carcinoma progression
    Br J Cancer.
    8.80
    2023-12
  • 解放军总医院第五医学中心
    Characteristics of blood immune cell profile and their correlation with disease progression in patients infected with HIV-1
    BMC Infect Dis.
    3.70
    2023-12
  • 华西口腔医院
    Mass cytometry and transcriptomic profiling reveal PD1 blockade induced alterations in oral carcinogenesis
    Mol Carcinog.
    4.60
    2023-12
  • 浙江大学医学院附属第一人民医院
    TP53/mTORC1-mediated bidirectional regulation of PD-L1 modulates immune evasion in hepatocellular carcinoma
    J Immunother Cancer.
    10.90
    2023-12
  • 广州市第一人民医院
    High-dimensional mass cytometry reveals systemic and local immune signatures in necrotizing enterocolitis
    Front Immunol.
    7.30
    2023-12
  • 上海交通大学医学院附属瑞金医院
    High-dimensional single-cell proteomics analysis of esophageal squamous cell carcinoma reveals dynamic alterations of the tumor immune microenvironment after neoadjuvant therapy
    J Immunother Cancer
    10.90
    2023-11
  • 福建医科大学附属协和医院
    Single-cell atlas reveals characteristic changes in intrahepatic HBV-specific leukocytes
    Microbiol Spectr.
    3,70
    2023-11
  • 长海医院
    CTM2-2023-06-1111: Targeting regulatory T-cells in pancreas during acute pancreatitis: Programmed-death 1 blockage as a potential therapeutic for infectious pancreatic necrosis
    Clin Transl Med.
    10.60
    2023-11
  • 浙江大学附属第二医院
    Age-Related Alterations in Peripheral Immune Landscape with Magnified Impact on Post-Stroke Brain
    Research (Wash D C).
    11.00
    2023-11
  • 南京医科大学附属第一医院
    Single-cell RNA-sequencing atlas reveals an FABP1-dependent immunosuppressive environment in hepatocellular carcinoma
    J Immunother Cancer
    10.90
    2023-11
  • 浙江大学附属第一医院
    Characteristics of circulating immune cells in HBV-related acute-on-chronic liver failure following artificial liver treatment
    BMC Immunol
    3.00
    2023-11
  • 广州市第一人民医院
    High-dimensional immune profiling using mass cytometry reveals IL-17A-producing γδT cells as biomarkers in patients with T-cell-activated idiopathic severe aplastic anemia
    Int Immunopharmacol
    5.60
    2023-11
  • 鲁南制药
    Intestinal flora, intestinal metabolism, and intestinal immunity changes in complete Freud's adjuvant-rheumatoid arthritis C57BL/6 mice
    Int Immunopharmacol
    5.60
    2023-10
  • 南京医科大学附属第一医院
    Endothelial DGKG promotes tumor angiogenesis and immune evasion in hepatocellular carcinoma
    Journal of Hepatology
    25.70
    2023-10
  • 复旦大学附属中山医院
    PGAM1 Inhibition Promotes HCC Ferroptosis and Synergizes with Anti-PD-1 Immunotherapy
    Adv Sci (Weinh)
    15.10
    2023-10
  • 上海交通大学医学院附属瑞金医院
    Systemic immune profiling of Omicron-infected subjects inoculated with different doses of inactivated virus vaccine
    Cell
    64.50
    2023-09
  • 上海市第一人民医院
    Temporal and spatial dynamics of immune cells in spontaneous liver transplant tolerance
    iScience
    5.80
    2023-09
  • 中国人民解放军总医院
    Mass cytometry reveals the corneal immune cell changes at single cell level in diabetic mice
    Front Endocrinol (Lausanne)
    5.20
    2023-09
  • 复旦大学附属华山医院
    Single-cell mapping reveals several immune subsets associated with liver metastasis of pancreatic ductal adenocarcinoma
    Med.
    17.00
    2023-08
  • 浙江大学医学院附属第一人民医院
    BMI1-induced CD127+KLRG1+ memory T cells enhance the efficacy of liver cancer immunotherapy
    Cancer Letters
    9.70
    2023-08
  • 复旦大学附属中山医院
    A single-cell transcriptional landscape of immune cells shows disease-specific changes of T cell and macrophage populations in human achalasia
    Nat Commun.
    16.60
    2023-08
  • 南方医科大学南方医院
    Tagering MS4A4A on tumour-associated macrophages restores CD8+T-cell-mediated antitumout immunity
    Gut
    24.50
    2023-07
  • 浙江大学附属第二医院
    Cytokine and chemokine map of peripheral specific immune cell subsets in Parkinson's disease
    NPJ Parkinsons Disease
    8.70
    2023-07
  • 浙江大学
    A gain-of-function variation in PLCG1 causes a new immune dysregulation disease
    J Allergy Clin Immunol
    14,20
    2023-07
  • 复旦大学附属中山医院
    Intratumoral PPT1-positive macrophages determine immunosuppressive contexture and immunotherapy response in hepatocellular carcinoma
    Journal for Immunotherapy of Cancer
    10.90
    2023-06
  • 复旦大学
    Hydroxyphenylpyruvate Dioxygenase Is a Metabolic Immune Checkpoint for UTX-deficient Colorectal Cancer
    Gastroenterology
    29.40
    2023-06
  • 浙江大学医学院附属第一医院
    Single-cell analysis reveals HBV-specific PD-1+CD8+ TRM cells in tumor borders are associated with HBV-related hepatic damage and fibrosis in HCC patients
    Clin Cancer Res
    11.50
    2023-06
  • 福建医科大学附属协和医院
    25-dimethylcelecoxib alleviated NK and T-cell exhaustion in hepatocellular carcinoma via the gastrointestinal microbiota-AMPK-mTOR axis
    J Immunother Cancer
    10.90
    2023-06
  • 浙江大学
    Identification of an IL-1 receptor mutation driving autoinflammation directs IL-1-targeted drug design
    Immunity
    32.40
    2023-06
  • 西南大学药学院医学研究所
    Breaking Spatiotemporal Barriers of Immunogenic Chemotherapy via an Endoplasmic Reticulum Membrane-Assisted Liposomal Drug Delivery
    ACS Nano
    17.10
    2023-05
  • 中国科学院北京基因组研究所
    Epigenetic reprogramming of RUNX3 reinforces CD8+T-cell function and improves the clinical response to immunotherapy
    Mol Cancer
    37.30
    2023-05
  • 浙江大学医学院附属第一医院
    Effects of 3-HAA on HCC by Regulating the HeterogeneousMacrophages—A scRNA-Seq Analysis
    Adv Sci (Weinh)
    15.10
    2023-04
  • 中国医学科学院血液病研究所
    Single-cell analysis highlights a population of Th17-polarized CD4 + naïve T cells showing IL6 / JAK3 / STAT3 activation in pediatric severe aplastic anemia
    J Autoimmun.
    12.80
    2023-03
  • 深圳大学医学院过敏与免疫学研究所
    Multidimensional Analysis of Lung Lymph Nodes in a Mouse Model of Allergic Lung Inflammation following PM2.5 and Indeno[1,2,3- cd ]pyrene Exposure
    Environ Health Perspect.
    10.40
    2023-03
  • 浙江大学附属第二医院
    Single-cell Profiling of Tumor Immune Microenvironment Reveals Immune Irresponsiveness in Gastric Signet-ring Cell Carcinoma
    Gastroenterology
    29.40
    2023-03
  • 鲁南制药
    Shouhui Tongbian Capsules induce regression of inflammation to improve intestinal barrier in mice with constipation by targeted binding to Prkaa1: With no obvious toxicity
    Biomedicine & Pharmacotherapy
    7.50
    2023-02
  • 复旦大学附属中山医院
    Disruption of SLFN11 deficiency-induced CCL2 signaling and macrophage M2 polarization potentiates anti-PD-1 therapy efficacy in hepatocellular carcinoma
    Gastroenterology
    29.40
    2023-02
  • 中国医学科学院北京协和医学院微循环研究所
    Mass Cytometry Reveals the Imbalanced Immune State in the Peripheral Blood of Patients with Essential Hypertension
    Cardiovasc Ther.
    3.10
    2023-02
  • 浙江大学附属儿童医院
    Comprehensive mapping of B lymphocyte immune dysfunction in idiopathic nephrotic syndrome children
    J Clin Invest.
    10.60
    2023-02
  • 中国人民解放军总医院
    Decitabine-priming increases anti-PD-1 antitumor efficacy by promoting CD8+ progenitor exhausted T-cell expansion in tumor models
    J Clin Invest.
    8.00
    2023-02
  • 浙江大学附属第二医院
    Secondary myeloid neoplasms after CD19 CAR T therapy in patients with refractory/relapsed B-cell lymphoma: Case series and review of literature
    Frontiers in Immunology
    8.786
    2023-01
  • 浙江大学附属第一医院
    An Ionic Liquid Ablation Agent for Local Ablation and Immune Activation in Pancreatic Cance
    Adv Sci (Weinh)
    17.521
    2023-01
  • 浙江省人民医院
    Depiction of immune heterogeneity of peripheral blood from patients with type II diabetic nephropathy based on mass cytometry
    Front Endocrinol (Lausanne)
    6.055
    2023-01
  • 北京大学深圳医院
    Phenotypic and functional alteration of CD45+ immune cells in the decidua of preeclampsia patients analyzed by mass cytometry (CyTOF)
    Frontiers in Immunolog
    8.786
    2023-01
  • 杭州市第一人民医院
    SULT2B1-CS-DOCK2 axis regulates effector T cell exhaustion in hepatocellular carcinoma microenvironment
    Hepatology.
    17.298
    2023-01
  • 广州中医药大学附属第二医院（广东省中医院）
    Single-Cell Analysis in Blood Reveals Distinct Immune Cell Profiles in Gouty Arthritis
    J Immunol.
    5.426
    2023-01
  • 南京医科大学附属第一医院
    Macrophage GSK3β-deficiency inhibits the progression of hepatocellular carcinoma and enhances the sensitivity of anti-PD1 immunotherapy
    Journal for ImmunoTherapy of Cancer
    12.469
    2022-12
  • 重庆医科大学附属第一医院
    Single-cell mapping reveals dysregulation of immune cell populations and VISTA+ monocytes in myasthenia gravis
    Clin Immunol.
    10.19
    2022-12
  • 香港中文大学理工学院深圳综合科学与技术研究院
    High-dimensional single-cell cartography tracking of immune cells subpopulation of mice peripheral blood treated with gold nanorods and black phosphorus nanosheets
    Nano Today
    18.962
    2022-11
  • 浙江大学附属第二医院
    The epidermal immune microenvironment plays a dominant role in psoriasis development, as revealed by mass cytometry
    Cell Mol Immunol.
    22.096
    2022-11
  • 浙江大学
    The immune landscape of human thymic epithelial tumors
    Nat Commun.
    17.694
    2022-10
  • 青岛大学附属青岛市立医院
    The Polygenic Map of Keloid Fibroblasts Reveals Fibrosis-Associated Gene Alterations in Inflammation and Immune Responses
    Frontiers in Immunolog
    8.786
    2022-10
  • 浙江大学附属第一医院
    Pyroptosis Remodeling Tumor Microenvironment to Enhance Pancreatic Cancer Immunotherapy Driven by Membrane Anchoring Photosensitizer
    Adv Sci (Weinh)
    17.521
    2022-10
  • 南京医科大学附属第一医院
    Inhibition of APOC1 promotes the transformation of M2 into M1 macrophages via the ferroptosis pathway and enhances anti-PD1 immunotherapy in hepatocellular carcinoma based on single-cell RNA sequencing
    Redox Biol
    10.787
    2022-10
  • 浙江大学附属第一医院
    Immune-infiltrating signature based classification reveals CD103+CD39+ T cells associate with colorectal cancer prognosis and response to immunotherapy
    Front Immunol.
    8.786
    2022-10
  • 浙江大学附属第一医院
    Comprehensive immune cell analysis of human menstrual-blood-derived stem cells therapy to concanavalin A hepatitis
    Front Immunol.
    8.786
    2022-09
  • 杭州市第一人民医院
    Prediction of tumor recurrence by distinct immunoprofiles in liver transplant patients based on mass cytometry
    Am J Cancer Res .
    5.942
    2022-09
  • 北京协和医院
    Single-cell profiling identifies mechanisms of inflammatory heterogeneity in chronic rhinosinusitis
    Nat Immunol
    31.250
    2022-09
  • 浙江大学附属第一医院
    Mass cytometry-based peripheral blood analysis as a novel tool for early detection of solid tumours: a multicentre study
    Gut
    31.793
    2022-09
  • 浙江大学附属第二医院
    High-dimensional Single-cell Analysis Delineates Peripheral Immune Signature of Coronary Atherosclerosis in Human Blood
    Theranostics
    11.600
    2022-09
  • 郑州大学第二附属医院
    Case report: Single-cell mapping of peripheral blood mononuclear cells from a patient with both Crohn's disease and isolated congenital asplenia
    Front Immunol.
    8.786
    2022-09
  • 北京协和医院
    Single-Cell Profiling of the Immune Atlas of Tumor-Infiltrating Lymphocytes in Endometrial Carcinoma
    Cancers (Basel).
    6.575
    2022-09
  • 南京医科大学附属第一医院
    Inhibition of APOE potentiates immune checkpoint therapy for cancer
    Int J Biol Sci
    10.75
    2022-08
  • 复旦大学附属中山医院
    Peripheral naïve CD8+ T cells as a predictive biomarker of response to lenvatinib plus an anti-PD-1 antibody in advanced hepatocellular carcinoma: a biomarker study
    Cancer Commun(Lond)
    15.283
    2022-08
  • 南京医科大学附属第一医院
    Over-Expression of GUSB Leads to Primary Resistance of Anti-PD1 Therapy in Hepatocellular Carcinoma
    Front Immunol.
    8.786
    2022-06
  • 南京医科大学附属第一医院
    MGP promotes CD8+ T cell exhaustion by activating the NF-κB pathway leading to liver metastasis of colorectal cancer
    Int J Biol Sci
    10.75
    2022-03
  • 浙江大学附属第一医院
    Engineered a dual-targeting biomimetic nanomedicine for pancreatic cancer chemoimmunotherapy
    Journal of Nanobiotechnology
    9.429
    2022-02
  • 浙江大学
    Applications of Single-Cell Omics in Tumor Immunology
    Frontiers in Immunolog
    8.786
    2021-06
  • 浙江大学附属第一医院
    Decoding the single-cell landscape and intercellular crosstalk in the transplanted liver: a 4-dimension mouse model
    Transplantation
    5.385
    2022-07
  • 浙江大学
    Metal-Chelatable Porphyrinic Frameworks for Single-Cell Multiplexing with Mass Cytometry
    Angew Chem Int Ed Engl.
    16.823
    2022-07
  • 广州呼吸健康研究院
    Immunoassay and mass cytometry revealed immunological profiles induced by inactivated BBIBP COVID-19 vaccine
    J Med Virol.
    20.693
    2022-07
  • 武汉大学口腔医学院
    Single-cell analysis reveals immune cellular components in odontogenic keratocysts
    Oral Dis
    4.068
    2022-06
  • 南京大学附属鼓楼医院
    Mass cytometry reveals immune atlas of urothelial carcinoma
    BMC cancer
    4.638
    2022-06
  • 浙江大学附属第一医院
    Dynamic Immune Landscape and VZV-Specific T Cell Responses in Patients With Herpes Zoster and Postherpetic Neuralgia
    Frontiers in Immunolog
    8.786
    2022-06
  • 山东大学
    Targeting tissue-resident memory CD8 + T cells in the kidney is a potential therapeutic strategy to ameliorate podocyte injury and glomerulosclerosis
    Molecular therapy
    12.910
    2022-05
  • 华西医院
    Integrating single-cell RNA sequencing with spatial transcriptomics reveals immune landscape for interstitial cystitis
    Signal Transduct Target Ther.
    38.104
    2022-05
  • 复旦大学肿瘤医院
    Hypoxia-reprogrammed regulatory group 2 innate lymphoid cells promote immunosuppression in pancreatic cancer
    eBioMedicine
    11.205
    2022-04
  • 复旦大学附属中山医院
    Interferon-α potentiates anti-PD-1 efficacy by remodeling glucose metabolism in the hepatocellular carcinoma microenvironment
    Cancer Discovery
    38.272
    2022-04
  • 北京大学人民医院
    Lung adenocarcinoma manifesting as subsolid nodule potentially represents tumor in the equilibrium phase of immunoediting
    Immunology
    7.251
    2022-03
  • 浙江大学附属第一医院
    Dynamic profiling of immune microenvironment during pancreatic cancer development suggests early intervention and combination strategy of immunotherapy
    eBioMedicine
    11.205
    2022-03
  • 浙江大学附属第一医院
    Combination cancer immunotherapy targeting TNFR2 and PD-1/PD-L1 signaling reduces immunosuppressive effects in the microenvironment of pancreatic tumors
    Journal for ImmunoTherapy of Cancer
    12.469
    2022-03
  • 浙江大学附属邵逸夫医院
    Systemic and single cell level responses to 1 nm size biomaterials demonstrate distinct biological effects revealed by multi-omics atlas
    Bioactive materials
    16.874
    2022-03
  • 复旦大学附属中山医院
    PKCα/ZFP64/CSF1 axis resets the tumor microenvironment and fuels anti-PD1 resistance in hepatocellular carcinoma
    Journal of hepatology
    30.083
    2022-02
  • 浙江大学附属第二医院
    Specific immune status in Parkinson's disease at different ages of onset
    npj Parkinson's Disease
    9.304
    2022-01
  • 浙江大学附属第一医院
    Single-Cell immune signature for detecting early-stage HCC and early assessing anti-PD-1 immunotherapy efficacy
    Journal for ImmunoTherapy of Cancer
    12.469
    2022-01
  • 中南大学湘雅医院
    Engineering an enthesis-like graft for rotator cuff repair: An approach to fabricate highly biomimetic scaffold capable of zone-specifically releasing stem cell differentiation inducers
    Bioactive materials
    16.874
    2022-01
  • 深圳市第三人民医院
    Discovery of CD3+CD19+ cells, a novel lymphocyte subset with a potential role in human immunodeficiency virus-Mycobacterium tuberculosis coinfection, using mass cytometry
    Clinical and translational medicine
    8.554
    2021-12
  • 浙江大学
    Rational administration sequencing of immunochemotherapy elicits powerful anti-tumor effect
    Journal of Controlled Release
    11.467
    2021-12
  • 长海医院
    An Immune Atlas of Nephrolithiasis: Single-Cell Mass Cytometryon SIRT3 Knockout and Calcium Oxalate-Induced Renal Injury
    Journal of Immunology Research
    4.493
    2021-11
  • 复旦大学附属中山医院
    A cellular census of human peripheral immune cells identifies novel cell states in lung diseases
    Clinical and translational medicine
    8.554
    2021-11
  • 南方医科大学珠江医院
    Single-Cell RNA Sequencing Reveals the Heterogeneity of Tumor-Associated Macrophage in Non-Small Cell Lung Cancer and Differences Between Sexes
    Frontiers in Immunolog
    8.786
    2021-11
  • 浙江大学
    Pro-Inflammatory Signature in Decidua of Recurrent Pregnancy Loss Regardless of Embryonic Chromosomal Abnormalities
    Frontiers in Immunolog
    8.786
    2021-11
  • 复旦大学附属瑞金医院
    Distinct immune signatures discriminate between asymptomatic and presymptomatic SARS-CoV-2 pos subjects
    Cell Research
    46.297
    2021-11
  • 河南省肿瘤医院
    Toxic Epidermal Necrolysis-Like Reaction Following Combination Therapy With Camrelizumab and Apatinib for Advanced Gallbladder Carcinoma
    Frontiers in oncology
    5.738
    2021-10
  • 华西医院
    Short Chain Fatty Acids Prevent Glyoxylate-Induced Calcium Oxalate Stones by GPR43-Dependent Immunomodulatory Mechanism
    Frontiers in Immunolog
    8.786
    2021-10
  • 复旦大学附属华山医院
    Distinct human Langerhans cell subsets orchestrate reciprocal functions and require different developmental regulation
    Immunity
    43.747
    2021-10
  • 南方医科大学珠江医院
    The Effect of Smoking on the Immune Microenvironment and Immunogenicity and Its Relationship With the Prognosis of Immune Checkpoint Inhibitors in Non-small Cell Lung Cancer
    Frontiers in cell and developmental biology
    6.081
    2021-09
  • ‎中国西安第四军医大学
    GDF15 induces immunosuppression via CD48 on regulatory T cells in hepatocellular carcinoma
    Journal for immunotherapy of cancer
    12.469
    2021-09
  • 浙江大学附属邵逸夫医院
    Estrogen inhibits the growth of colon cancer in mice through reversing extracellular vesicle-mediated immunosuppressive tumor microenvironment
    Cancer Letters
    9.756
    2021-08
  • 浙江大学附属第二医院
    Fresh tissue multi-omics profiling reveals immune classification and suggests immunotherapy candidates of conwentional chondrosarcoma
    clinical cancer research
    13.801
    2021-08
  • 浙江大学
    GdClean: removal of Gadolinium contamination in mass cytometry data
    Bioinformatics
    6.931
    2021-07
  • 广东省人民医院
    DAGM: A novel modelling framework to assess the risk of HER2-negative breast cancer based on germline rare coding mutations
    EBioMedicine
    11.205
    2021-07
  • 浙江大学
    Mass cytometry and transcriptomic profiling reveal body-wide pathology induced by Loxl1 deficiency
    Cell Prolification
    8.755
    2021-06
  • 南方医科大学珠江医院
    Single-Cell Profiling of Kidney Transplant Recipients With Immunosuppressive Treatment Reveals the Dynamic Immune Characteristics
    Frontiers in Immunolog
    8.786
    2021-04
  • 浙江大学附属第一医院
    Group-2 Innate Lymphoid Cells Promote Hepatocellular Carcinoma Progression via CXCL2-Neutrophil Induced Immunosuppression
    Hepatology
    17.298
    2021-04
  • 医学科学院&中国民族大学
    Microglial deletion and inhibition alleviate behavior of post-traumatic stress disorder in mice
    Journal of neuroinflammation
    9.587
    2021-01
  • 浙江大学附属第一医院
    Mesenchymal stem cell-mediated immunomodulation of recruited mononuclear phagocytes during acute lung injury: a high-dimensional analysis study
    Theranostics
    11.600
    2021-01
  • 复旦大学附属瑞金医院
    Soluble PD-L1 improved direct ARDS by reducing monocyte-derived macrophages
    Cell Death & Disease
    9.685
    2020-10
  • 浙江大学附属第一医院
    Mesenchymal stem cells alleviate LPS-induced acute lung injury by inhibiting the proinflammatory function of Ly6C + CD8 + T cells
    Cell Death & Disease
    9.685
    2020-10
  • 复旦大学附属中山医院
    Global Immunometabolic Profiling of AECOPD
    Small Methods
    15.367
    2020-10
  • 浙江大学附属邵逸夫医院
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