普罗亭 普罗亭
单细胞测序服务
快速进行单细胞的标记、建库、测序和分析,高效获得上万个单细胞的基因表达谱。
技术原理 技术特点 应用方向 服务流程 样本要求 样本类型 数据分析 服务成果
普罗亭
技术原理
10X Genomics 单细胞转录组测序平台利用微流控和 barcode 标记等技术,捕获近十万个细胞,从而获得大量的转录组信息。该过程通量高、成本低、周期短。
技术特点
普罗亭

通量高 一次测序,同时可检测8个通道,每个通道一次可捕获10000个细胞,一次实验可分选标记80000个细胞

普罗亭

周期短 完成上万个细胞封装仅需6分钟内,完成单细胞悬液、细胞捕获、扩增以及建库仅需1天

普罗亭

精度高 真正意义上实现对单个细胞的测序,每一个细胞形成单独的GEMs

普罗亭

超多维度 单个细胞捕获效率高达65%

普罗亭

范围广 可以广泛应用于个体异质性、免疫微环境、神经科学、胚胎发育、细胞分化等领域的研究

普罗亭

类型多 细胞类型多样化,对细胞大小要求低(适宜40 μm直径以内),无下限

普罗亭
应用方向
服务流程
普罗亭采用多对一的项目合作模式,针对单个项目建立包含多名专业技术人员的专项团队。
深入了解客户需求,从合同签订到结项报告全流程有效沟通并严格质控。提供更加专业、放心的质谱流式完整解决方案。
普罗亭
普罗亭
样本要求
  • 样品类型
    样品类型
    新鲜人或小鼠细胞悬液、血液 (全血、PBMC等)
  • 细胞总数
    细胞总数
    细胞悬液,一个样本细胞起 始量约2.0x105个。
  • 质量要求
    质量要求
    细胞活性大于85%,理想浓 度约为1000个/ul
  • 培养需求
    培养需求
    细胞培养基及缓冲液不能含有Ca2+和Mg2+等影响酶活性的物质
样本类型
人源样本包括肝癌、肺癌、胃癌等癌组织和斑块、血管、 皮肤等非癌组织。
小鼠样本包括小肠癌、直肠癌、黑色素瘤等癌组织和脑膜,心脏、骨髓等非癌组织。
涉及实体瘤、血液病、自身免疫病、心血管疾病、呼吸系统疾病等多个领域,每年检测量超10000例。
普罗亭
人源样本
普罗亭
小鼠样本
数据分析
普罗亭生信分析团队的核心科学家博士毕业于美国拥有顶级生物医学工程专业 的佐治亚理工学院,核心算法的系列
软件均为自主研发,拥有正式授权的软件著作权35项。能够为客户提供定制化的数据挖掘方案,满足多样化的数据分析挖掘需求。
普罗亭
普罗亭
普罗亭
普罗亭
普罗亭
普罗亭
普罗亭
普罗亭
普罗亭
普罗亭
普罗亭
UMAP
降维可视化展示不同cluster、group细胞以及marker表达的空间分布
Frequency bar
展示不同group间不同cluster细胞数量的占比
correlation
展示细胞群之间的相关性
Violin plot
展示基因在各个样本中的表达情况
dotplot
统计学分析出不同group间差异的细胞表型
Volcano plot
展示基因的差异表达情况
3D Pseudotime
拟时序分析细胞群体发育轨迹
Pseudotime
预测细胞的分化及发育轨迹
GO/KEGG Enrichment
系统分析基因产物在细胞中的代谢途径及其功能
Interaction network map
差异基因蛋白网络互作分析
heatmap
展示亚群cluster与其marker表达模式
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服务成果
文献130篇,累计IF>1800,平均15,10分以上达50%
  • 合作单位
    发表文章
    发表期刊
    IF
    发表时间
  • 浙江大学医学院附属第二医院
    Camrelizumab,chemotherapy and apatinib in the neoadjuvant treatment of resectable oesophageal squamous cell carcinoma:a single-arm phase 2 trial
    EClinicalMedicine.
    15.10
    2024-04
  • 上海交通大学医学院附属瑞金医院
    Identiication of clinically relevant subsets CD39+PD-1+CD8+T cells and CD39+ regulatory T cells in intraphepatic cholangiocarinoma using single-cell CyTOF
    Transl Oncol
    5.00
    2024-04
  • 北京协和医学院皮肤病研究所
    Circulating Immune Landscape Profiling in Psoriasis Vigaris and Psoriatic Arthritis by Mass Cytometry
    J Immunol Res.
    4.10
    2024-04
  • 北京大学第三医院
    A generalizable and easy-to-use COVID-19 stratification model for the next pandemic via immune-phenotyping and machine learning
    Front Immunol.
    7.30
    2024-04
  • 复旦大学附属中山医院
    Repolarization of immunosuppressive macrophages by targeting SLAMF7-regulated CCL2 singaling sensitizes hepatocellular carcinoma to immunotherapy
    Cecer Res.
    11.20
    2024-04
  • 浙江大学医学院第二附属医院
    Targeting pro-inflammatory T cells as a novel therapeutic approach to potentially resolve atherosclerosis in humans
    Cell Research
    44.10
    2024-03
  • 南京大学南京鼓楼医院
    Immune profiling analysis of double-negative T cells in patients with systemic sclerosis
    Clin Rheumatol.
    3.40
    2024-03
  • 浙江大学医学院第二附属医院
    Circulation immune cell landscape in canonical pathogenesis of colorectal adenocarcinoma by CyTOF analysis
    iScience
    5.80
    2024-02
  • 复旦大学中山医院
    CRKL dictates anti-PD-1 resistance by mediating tumor-associated neutrophil infiltration in hepatocellular carcinoma
    J Hepatol
    25.70
    2024-02
  • 上海胸科医院
    ADGRE5-centered Tsurv model in T cells recognizes responders to neoadjuvant cancer immunotherapy
    Front Immunol.
    7.30
    2024-02
  • 浙江大学医学院附属第一医院
    CD57-positive CD8+ T cells define the response anti-programmed cell death protein-1 immunotherapy in patients with advanced non-small cell lung cancer
    NPJ Precis Oncol.
    7.90
    2024-01
  • 安徽医科大学第二附属医院
    Macrophages promote the transition from myocardial ischemia reperfusion injury to cardiac fibrosis in mice through GMCSF/CCL2/CCR2 and phenotype switching
    Acta Pharmacol Sin.
    8.20
    2024-01
  • 安徽医科大学第二附属医院
    Single-cell RNA sequencing reveals S100a9hi macrophages promote the transition from acute inflammation to fibrotic remodeling after myocardial ischemia‒reperfusion
    Theranostics
    12.40
    2024-01
  • 国家纳米科学中心
    Durable and enhanced immunity against SARS-CoV-2 elicited by manganese nanoadjuvant formulated subunit vaccine formulated subunit vaccine
    Signal Transduct Target Ther.
    39.30
    2023-12
  • 江苏省人民医院
    Ultrasound-responsive spherical nucleic acid against c-Myc/PD-L1 to enhance anti-tumoralmacrophages in triple-negative breast cancer progression
    Sci China Life Sci
    9.10
    2023-12
  • 北京协和医院
    PD-1 and TIGIT coexpressing CD8 + CD103 + tissue-resident memory cells in endometrial cancer as potential targets for immunotherapy
    International Immunopharmacology
    5.60
    2023-12
  • 福建医科大学附属协和医院
    Correction to: A modified immune cell infiltration score achieves ideal stratification for CD8+ T cell efficacy and immunotherapy benefit in hepatocellular carcinoma
    Cancer Immunol Immunother.
    5.80
    2023-12
  • 福建医科大学附属协和医院
    TGF-β-p-STAT1-LAIR2 axis has a "self-rescue" role for exhausted CD8+ T cells in hepatocellular carcinoma
    Cell Oncol (Dordr).
    6.60
    2023-12
  • 福建医科大学附属协和医院
    SUMOylation inhibitors activate anti-tumor immunity by reshaping the immune microenvironment in a preclinical model of hepatocellular carcinoma
    Cell Oncol (Dordr).
    6.60
    2023-12
  • 浙江大学
    Downregulation of N4-acetylcytidine modification in myeloid cells attenuates immunotherapy and exacerbates hepatocellular carcinoma progression
    Br J Cancer.
    8.80
    2023-12
  • 解放军总医院第五医学中心
    Characteristics of blood immune cell profile and their correlation with disease progression in patients infected with HIV-1
    BMC Infect Dis.
    3.70
    2023-12
  • 华西口腔医院
    Mass cytometry and transcriptomic profiling reveal PD1 blockade induced alterations in oral carcinogenesis
    Mol Carcinog.
    4.60
    2023-12
  • 浙江大学医学院附属第一人民医院
    TP53/mTORC1-mediated bidirectional regulation of PD-L1 modulates immune evasion in hepatocellular carcinoma
    J Immunother Cancer.
    10.90
    2023-12
  • 广州市第一人民医院
    High-dimensional mass cytometry reveals systemic and local immune signatures in necrotizing enterocolitis
    Front Immunol.
    7.30
    2023-12
  • 上海交通大学医学院附属瑞金医院
    High-dimensional single-cell proteomics analysis of esophageal squamous cell carcinoma reveals dynamic alterations of the tumor immune microenvironment after neoadjuvant therapy
    J Immunother Cancer
    10.90
    2023-11
  • 福建医科大学附属协和医院
    Single-cell atlas reveals characteristic changes in intrahepatic HBV-specific leukocytes
    Microbiol Spectr.
    3,70
    2023-11
  • 长海医院
    CTM2-2023-06-1111: Targeting regulatory T-cells in pancreas during acute pancreatitis: Programmed-death 1 blockage as a potential therapeutic for infectious pancreatic necrosis
    Clin Transl Med.
    10.60
    2023-11
  • 浙江大学附属第二医院
    Age-Related Alterations in Peripheral Immune Landscape with Magnified Impact on Post-Stroke Brain
    Research (Wash D C).
    11.00
    2023-11
  • 南京医科大学附属第一医院
    Single-cell RNA-sequencing atlas reveals an FABP1-dependent immunosuppressive environment in hepatocellular carcinoma
    J Immunother Cancer
    10.90
    2023-11
  • 浙江大学附属第一医院
    Characteristics of circulating immune cells in HBV-related acute-on-chronic liver failure following artificial liver treatment
    BMC Immunol
    3.00
    2023-11
  • 广州市第一人民医院
    High-dimensional immune profiling using mass cytometry reveals IL-17A-producing γδT cells as biomarkers in patients with T-cell-activated idiopathic severe aplastic anemia
    Int Immunopharmacol
    5.60
    2023-11
  • 鲁南制药
    Intestinal flora, intestinal metabolism, and intestinal immunity changes in complete Freud's adjuvant-rheumatoid arthritis C57BL/6 mice
    Int Immunopharmacol
    5.60
    2023-10
  • 南京医科大学附属第一医院
    Endothelial DGKG promotes tumor angiogenesis and immune evasion in hepatocellular carcinoma
    Journal of Hepatology
    25.70
    2023-10
  • 复旦大学附属中山医院
    PGAM1 Inhibition Promotes HCC Ferroptosis and Synergizes with Anti-PD-1 Immunotherapy
    Adv Sci (Weinh)
    15.10
    2023-10
  • 上海交通大学医学院附属瑞金医院
    Systemic immune profiling of Omicron-infected subjects inoculated with different doses of inactivated virus vaccine
    Cell
    64.50
    2023-09
  • 上海市第一人民医院
    Temporal and spatial dynamics of immune cells in spontaneous liver transplant tolerance
    iScience
    5.80
    2023-09
  • 中国人民解放军总医院
    Mass cytometry reveals the corneal immune cell changes at single cell level in diabetic mice
    Front Endocrinol (Lausanne)
    5.20
    2023-09
  • 复旦大学附属华山医院
    Single-cell mapping reveals several immune subsets associated with liver metastasis of pancreatic ductal adenocarcinoma
    Med.
    17.00
    2023-08
  • 浙江大学医学院附属第一人民医院
    BMI1-induced CD127+KLRG1+ memory T cells enhance the efficacy of liver cancer immunotherapy
    Cancer Letters
    9.70
    2023-08
  • 复旦大学附属中山医院
    A single-cell transcriptional landscape of immune cells shows disease-specific changes of T cell and macrophage populations in human achalasia
    Nat Commun.
    16.60
    2023-08
  • 南方医科大学南方医院
    Tagering MS4A4A on tumour-associated macrophages restores CD8+T-cell-mediated antitumout immunity
    Gut
    24.50
    2023-07
  • 浙江大学附属第二医院
    Cytokine and chemokine map of peripheral specific immune cell subsets in Parkinson's disease
    NPJ Parkinsons Disease
    8.70
    2023-07
  • 浙江大学
    A gain-of-function variation in PLCG1 causes a new immune dysregulation disease
    J Allergy Clin Immunol
    14,20
    2023-07
  • 复旦大学附属中山医院
    Intratumoral PPT1-positive macrophages determine immunosuppressive contexture and immunotherapy response in hepatocellular carcinoma
    Journal for Immunotherapy of Cancer
    10.90
    2023-06
  • 复旦大学
    Hydroxyphenylpyruvate Dioxygenase Is a Metabolic Immune Checkpoint for UTX-deficient Colorectal Cancer
    Gastroenterology
    29.40
    2023-06
  • 浙江大学医学院附属第一医院
    Single-cell analysis reveals HBV-specific PD-1+CD8+ TRM cells in tumor borders are associated with HBV-related hepatic damage and fibrosis in HCC patients
    Clin Cancer Res
    11.50
    2023-06
  • 福建医科大学附属协和医院
    25-dimethylcelecoxib alleviated NK and T-cell exhaustion in hepatocellular carcinoma via the gastrointestinal microbiota-AMPK-mTOR axis
    J Immunother Cancer
    10.90
    2023-06
  • 浙江大学
    Identification of an IL-1 receptor mutation driving autoinflammation directs IL-1-targeted drug design
    Immunity
    32.40
    2023-06
  • 西南大学药学院医学研究所
    Breaking Spatiotemporal Barriers of Immunogenic Chemotherapy via an Endoplasmic Reticulum Membrane-Assisted Liposomal Drug Delivery
    ACS Nano
    17.10
    2023-05
  • 中国科学院北京基因组研究所
    Epigenetic reprogramming of RUNX3 reinforces CD8+T-cell function and improves the clinical response to immunotherapy
    Mol Cancer
    37.30
    2023-05
  • 浙江大学医学院附属第一医院
    Effects of 3-HAA on HCC by Regulating the HeterogeneousMacrophages—A scRNA-Seq Analysis
    Adv Sci (Weinh)
    15.10
    2023-04
  • 中国医学科学院血液病研究所
    Single-cell analysis highlights a population of Th17-polarized CD4 + naïve T cells showing IL6 / JAK3 / STAT3 activation in pediatric severe aplastic anemia
    J Autoimmun.
    12.80
    2023-03
  • 深圳大学医学院过敏与免疫学研究所
    Multidimensional Analysis of Lung Lymph Nodes in a Mouse Model of Allergic Lung Inflammation following PM2.5 and Indeno[1,2,3- cd ]pyrene Exposure
    Environ Health Perspect.
    10.40
    2023-03
  • 浙江大学附属第二医院
    Single-cell Profiling of Tumor Immune Microenvironment Reveals Immune Irresponsiveness in Gastric Signet-ring Cell Carcinoma
    Gastroenterology
    29.40
    2023-03
  • 鲁南制药
    Shouhui Tongbian Capsules induce regression of inflammation to improve intestinal barrier in mice with constipation by targeted binding to Prkaa1: With no obvious toxicity
    Biomedicine & Pharmacotherapy
    7.50
    2023-02
  • 复旦大学附属中山医院
    Disruption of SLFN11 deficiency-induced CCL2 signaling and macrophage M2 polarization potentiates anti-PD-1 therapy efficacy in hepatocellular carcinoma
    Gastroenterology
    29.40
    2023-02
  • 中国医学科学院北京协和医学院微循环研究所
    Mass Cytometry Reveals the Imbalanced Immune State in the Peripheral Blood of Patients with Essential Hypertension
    Cardiovasc Ther.
    3.10
    2023-02
  • 浙江大学附属儿童医院
    Comprehensive mapping of B lymphocyte immune dysfunction in idiopathic nephrotic syndrome children
    J Clin Invest.
    10.60
    2023-02
  • 中国人民解放军总医院
    Decitabine-priming increases anti-PD-1 antitumor efficacy by promoting CD8+ progenitor exhausted T-cell expansion in tumor models
    J Clin Invest.
    8.00
    2023-02
  • 浙江大学附属第二医院
    Secondary myeloid neoplasms after CD19 CAR T therapy in patients with refractory/relapsed B-cell lymphoma: Case series and review of literature
    Frontiers in Immunology
    8.786
    2023-01
  • 浙江大学附属第一医院
    An Ionic Liquid Ablation Agent for Local Ablation and Immune Activation in Pancreatic Cance
    Adv Sci (Weinh)
    17.521
    2023-01
  • 浙江省人民医院
    Depiction of immune heterogeneity of peripheral blood from patients with type II diabetic nephropathy based on mass cytometry
    Front Endocrinol (Lausanne)
    6.055
    2023-01
  • 北京大学深圳医院
    Phenotypic and functional alteration of CD45+ immune cells in the decidua of preeclampsia patients analyzed by mass cytometry (CyTOF)
    Frontiers in Immunolog
    8.786
    2023-01
  • 杭州市第一人民医院
    SULT2B1-CS-DOCK2 axis regulates effector T cell exhaustion in hepatocellular carcinoma microenvironment
    Hepatology.
    17.298
    2023-01
  • 广州中医药大学附属第二医院(广东省中医院)
    Single-Cell Analysis in Blood Reveals Distinct Immune Cell Profiles in Gouty Arthritis
    J Immunol.
    5.426
    2023-01
  • 南京医科大学附属第一医院
    Macrophage GSK3β-deficiency inhibits the progression of hepatocellular carcinoma and enhances the sensitivity of anti-PD1 immunotherapy
    Journal for ImmunoTherapy of Cancer
    12.469
    2022-12
  • 重庆医科大学附属第一医院
    Single-cell mapping reveals dysregulation of immune cell populations and VISTA+ monocytes in myasthenia gravis
    Clin Immunol.
    10.19
    2022-12
  • 香港中文大学理工学院深圳综合科学与技术研究院
    High-dimensional single-cell cartography tracking of immune cells subpopulation of mice peripheral blood treated with gold nanorods and black phosphorus nanosheets
    Nano Today
    18.962
    2022-11
  • 浙江大学附属第二医院
    The epidermal immune microenvironment plays a dominant role in psoriasis development, as revealed by mass cytometry
    Cell Mol Immunol.
    22.096
    2022-11
  • 浙江大学
    The immune landscape of human thymic epithelial tumors
    Nat Commun.
    17.694
    2022-10
  • 青岛大学附属青岛市立医院
    The Polygenic Map of Keloid Fibroblasts Reveals Fibrosis-Associated Gene Alterations in Inflammation and Immune Responses
    Frontiers in Immunolog
    8.786
    2022-10
  • 浙江大学附属第一医院
    Pyroptosis Remodeling Tumor Microenvironment to Enhance Pancreatic Cancer Immunotherapy Driven by Membrane Anchoring Photosensitizer
    Adv Sci (Weinh)
    17.521
    2022-10
  • 南京医科大学附属第一医院
    Inhibition of APOC1 promotes the transformation of M2 into M1 macrophages via the ferroptosis pathway and enhances anti-PD1 immunotherapy in hepatocellular carcinoma based on single-cell RNA sequencing
    Redox Biol
    10.787
    2022-10
  • 浙江大学附属第一医院
    Immune-infiltrating signature based classification reveals CD103+CD39+ T cells associate with colorectal cancer prognosis and response to immunotherapy
    Front Immunol.
    8.786
    2022-10
  • 浙江大学附属第一医院
    Comprehensive immune cell analysis of human menstrual-blood-derived stem cells therapy to concanavalin A hepatitis
    Front Immunol.
    8.786
    2022-09
  • 杭州市第一人民医院
    Prediction of tumor recurrence by distinct immunoprofiles in liver transplant patients based on mass cytometry
    Am J Cancer Res .
    5.942
    2022-09
  • 北京协和医院
    Single-cell profiling identifies mechanisms of inflammatory heterogeneity in chronic rhinosinusitis
    Nat Immunol
    31.250
    2022-09
  • 浙江大学附属第一医院
    Mass cytometry-based peripheral blood analysis as a novel tool for early detection of solid tumours: a multicentre study
    Gut
    31.793
    2022-09
  • 浙江大学附属第二医院
    High-dimensional Single-cell Analysis Delineates Peripheral Immune Signature of Coronary Atherosclerosis in Human Blood
    Theranostics
    11.600
    2022-09
  • 郑州大学第二附属医院
    Case report: Single-cell mapping of peripheral blood mononuclear cells from a patient with both Crohn's disease and isolated congenital asplenia
    Front Immunol.
    8.786
    2022-09
  • 北京协和医院
    Single-Cell Profiling of the Immune Atlas of Tumor-Infiltrating Lymphocytes in Endometrial Carcinoma
    Cancers (Basel).
    6.575
    2022-09
  • 南京医科大学附属第一医院
    Inhibition of APOE potentiates immune checkpoint therapy for cancer
    Int J Biol Sci
    10.75
    2022-08
  • 复旦大学附属中山医院
    Peripheral naïve CD8+ T cells as a predictive biomarker of response to lenvatinib plus an anti-PD-1 antibody in advanced hepatocellular carcinoma: a biomarker study
    Cancer Commun(Lond)
    15.283
    2022-08
  • 南京医科大学附属第一医院
    Over-Expression of GUSB Leads to Primary Resistance of Anti-PD1 Therapy in Hepatocellular Carcinoma
    Front Immunol.
    8.786
    2022-06
  • 南京医科大学附属第一医院
    MGP promotes CD8+ T cell exhaustion by activating the NF-κB pathway leading to liver metastasis of colorectal cancer
    Int J Biol Sci
    10.75
    2022-03
  • 浙江大学附属第一医院
    Engineered a dual-targeting biomimetic nanomedicine for pancreatic cancer chemoimmunotherapy
    Journal of Nanobiotechnology
    9.429
    2022-02
  • 浙江大学
    Applications of Single-Cell Omics in Tumor Immunology
    Frontiers in Immunolog
    8.786
    2021-06
  • 浙江大学附属第一医院
    Decoding the single-cell landscape and intercellular crosstalk in the transplanted liver: a 4-dimension mouse model
    Transplantation
    5.385
    2022-07
  • 浙江大学
    Metal-Chelatable Porphyrinic Frameworks for Single-Cell Multiplexing with Mass Cytometry
    Angew Chem Int Ed Engl.
    16.823
    2022-07
  • 广州呼吸健康研究院
    Immunoassay and mass cytometry revealed immunological profiles induced by inactivated BBIBP COVID-19 vaccine
    J Med Virol.
    20.693
    2022-07
  • 武汉大学口腔医学院
    Single-cell analysis reveals immune cellular components in odontogenic keratocysts
    Oral Dis
    4.068
    2022-06
  • 南京大学附属鼓楼医院
    Mass cytometry reveals immune atlas of urothelial carcinoma
    BMC cancer
    4.638
    2022-06
  • 浙江大学附属第一医院
    Dynamic Immune Landscape and VZV-Specific T Cell Responses in Patients With Herpes Zoster and Postherpetic Neuralgia
    Frontiers in Immunolog
    8.786
    2022-06
  • 山东大学
    Targeting tissue-resident memory CD8 + T cells in the kidney is a potential therapeutic strategy to ameliorate podocyte injury and glomerulosclerosis
    Molecular therapy
    12.910
    2022-05
  • 华西医院
    Integrating single-cell RNA sequencing with spatial transcriptomics reveals immune landscape for interstitial cystitis
    Signal Transduct Target Ther.
    38.104
    2022-05
  • 复旦大学肿瘤医院
    Hypoxia-reprogrammed regulatory group 2 innate lymphoid cells promote immunosuppression in pancreatic cancer
    eBioMedicine
    11.205
    2022-04
  • 复旦大学附属中山医院
    Interferon-α potentiates anti-PD-1 efficacy by remodeling glucose metabolism in the hepatocellular carcinoma microenvironment
    Cancer Discovery
    38.272
    2022-04
  • 北京大学人民医院
    Lung adenocarcinoma manifesting as subsolid nodule potentially represents tumor in the equilibrium phase of immunoediting
    Immunology
    7.251
    2022-03
  • 浙江大学附属第一医院
    Dynamic profiling of immune microenvironment during pancreatic cancer development suggests early intervention and combination strategy of immunotherapy
    eBioMedicine
    11.205
    2022-03
  • 浙江大学附属第一医院
    Combination cancer immunotherapy targeting TNFR2 and PD-1/PD-L1 signaling reduces immunosuppressive effects in the microenvironment of pancreatic tumors
    Journal for ImmunoTherapy of Cancer
    12.469
    2022-03
  • 浙江大学附属邵逸夫医院
    Systemic and single cell level responses to 1 nm size biomaterials demonstrate distinct biological effects revealed by multi-omics atlas
    Bioactive materials
    16.874
    2022-03
  • 复旦大学附属中山医院
    PKCα/ZFP64/CSF1 axis resets the tumor microenvironment and fuels anti-PD1 resistance in hepatocellular carcinoma
    Journal of hepatology
    30.083
    2022-02
  • 浙江大学附属第二医院
    Specific immune status in Parkinson's disease at different ages of onset
    npj Parkinson's Disease
    9.304
    2022-01
  • 浙江大学附属第一医院
    Single-Cell immune signature for detecting early-stage HCC and early assessing anti-PD-1 immunotherapy efficacy
    Journal for ImmunoTherapy of Cancer
    12.469
    2022-01
  • 中南大学湘雅医院
    Engineering an enthesis-like graft for rotator cuff repair: An approach to fabricate highly biomimetic scaffold capable of zone-specifically releasing stem cell differentiation inducers
    Bioactive materials
    16.874
    2022-01
  • 深圳市第三人民医院
    Discovery of CD3+CD19+ cells, a novel lymphocyte subset with a potential role in human immunodeficiency virus-Mycobacterium tuberculosis coinfection, using mass cytometry
    Clinical and translational medicine
    8.554
    2021-12
  • 浙江大学
    Rational administration sequencing of immunochemotherapy elicits powerful anti-tumor effect
    Journal of Controlled Release
    11.467
    2021-12
  • 长海医院
    An Immune Atlas of Nephrolithiasis: Single-Cell Mass Cytometryon SIRT3 Knockout and Calcium Oxalate-Induced Renal Injury
    Journal of Immunology Research
    4.493
    2021-11
  • 复旦大学附属中山医院
    A cellular census of human peripheral immune cells identifies novel cell states in lung diseases
    Clinical and translational medicine
    8.554
    2021-11
  • 南方医科大学珠江医院
    Single-Cell RNA Sequencing Reveals the Heterogeneity of Tumor-Associated Macrophage in Non-Small Cell Lung Cancer and Differences Between Sexes
    Frontiers in Immunolog
    8.786
    2021-11
  • 浙江大学
    Pro-Inflammatory Signature in Decidua of Recurrent Pregnancy Loss Regardless of Embryonic Chromosomal Abnormalities
    Frontiers in Immunolog
    8.786
    2021-11
  • 复旦大学附属瑞金医院
    Distinct immune signatures discriminate between asymptomatic and presymptomatic SARS-CoV-2 pos subjects
    Cell Research
    46.297
    2021-11
  • 河南省肿瘤医院
    Toxic Epidermal Necrolysis-Like Reaction Following Combination Therapy With Camrelizumab and Apatinib for Advanced Gallbladder Carcinoma
    Frontiers in oncology
    5.738
    2021-10
  • 华西医院
    Short Chain Fatty Acids Prevent Glyoxylate-Induced Calcium Oxalate Stones by GPR43-Dependent Immunomodulatory Mechanism
    Frontiers in Immunolog
    8.786
    2021-10
  • 复旦大学附属华山医院
    Distinct human Langerhans cell subsets orchestrate reciprocal functions and require different developmental regulation
    Immunity
    43.747
    2021-10
  • 南方医科大学珠江医院
    The Effect of Smoking on the Immune Microenvironment and Immunogenicity and Its Relationship With the Prognosis of Immune Checkpoint Inhibitors in Non-small Cell Lung Cancer
    Frontiers in cell and developmental biology
    6.081
    2021-09
  • ‎中国西安第四军医大学
    GDF15 induces immunosuppression via CD48 on regulatory T cells in hepatocellular carcinoma
    Journal for immunotherapy of cancer
    12.469
    2021-09
  • 浙江大学附属邵逸夫医院
    Estrogen inhibits the growth of colon cancer in mice through reversing extracellular vesicle-mediated immunosuppressive tumor microenvironment
    Cancer Letters
    9.756
    2021-08
  • 浙江大学附属第二医院
    Fresh tissue multi-omics profiling reveals immune classification and suggests immunotherapy candidates of conwentional chondrosarcoma
    clinical cancer research
    13.801
    2021-08
  • 浙江大学
    GdClean: removal of Gadolinium contamination in mass cytometry data
    Bioinformatics
    6.931
    2021-07
  • 广东省人民医院
    DAGM: A novel modelling framework to assess the risk of HER2-negative breast cancer based on germline rare coding mutations
    EBioMedicine
    11.205
    2021-07
  • 浙江大学
    Mass cytometry and transcriptomic profiling reveal body-wide pathology induced by Loxl1 deficiency
    Cell Prolification
    8.755
    2021-06
  • 南方医科大学珠江医院
    Single-Cell Profiling of Kidney Transplant Recipients With Immunosuppressive Treatment Reveals the Dynamic Immune Characteristics
    Frontiers in Immunolog
    8.786
    2021-04
  • 浙江大学附属第一医院
    Group-2 Innate Lymphoid Cells Promote Hepatocellular Carcinoma Progression via CXCL2-Neutrophil Induced Immunosuppression
    Hepatology
    17.298
    2021-04
  • 医学科学院&中国民族大学
    Microglial deletion and inhibition alleviate behavior of post-traumatic stress disorder in mice
    Journal of neuroinflammation
    9.587
    2021-01
  • 浙江大学附属第一医院
    Mesenchymal stem cell-mediated immunomodulation of recruited mononuclear phagocytes during acute lung injury: a high-dimensional analysis study
    Theranostics
    11.600
    2021-01
  • 复旦大学附属瑞金医院
    Soluble PD-L1 improved direct ARDS by reducing monocyte-derived macrophages
    Cell Death & Disease
    9.685
    2020-10
  • 浙江大学附属第一医院
    Mesenchymal stem cells alleviate LPS-induced acute lung injury by inhibiting the proinflammatory function of Ly6C + CD8 + T cells
    Cell Death & Disease
    9.685
    2020-10
  • 复旦大学附属中山医院
    Global Immunometabolic Profiling of AECOPD
    Small Methods
    15.367
    2020-10
  • 浙江大学附属邵逸夫医院
    BxPC-3-Derived Small Extracellular Vesicles Induce FOXP3+ Treg through ATM-AMPK-Sirtuins-Mediated FOXOs Nuclear Translocations
    iScience
    6.107
    2020-08
  • 浙江大学附属第一医院
    Potent Anti-Tumor Activity of Bcma CAR-T Therapy Against Heavily Treated Multiple Myeloma and Dynamics of Immune Cell Subsets Using Single-Cell Mass Cytometry
    Blood (poster)
    25.476
    2019-11
  • 浙江大学附属第一医院
    Integrated multiomic analysis reveals comprehensive tumour hetero-geneity and novel immunophenotypic classification in hepatocellular carcinomas
    Gut
    31.793
    2019-11
  • 南京大学
    Role of CXCR3 signaling in response to anti-PD-1 therap
    EBioMedicine
    11.205
    2019-10
  • 浙江大学
    Single-cell mass cytometry reveals in vivo immunological response to surgical biomaterials
    Applied Materials Today
    8.663
    2019-09
  • 浙江大学附属第一医院
    Immunomodulatory effect of mesenchymal stem cells in chemical-induced liver injury:a high-dimensional analysis
    Stem Cell Research & Therapy
    8.079
    2019-08
  • 美国耶鲁大学
    Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3
    Cell
    66.850
    2019-01
武汉大学武汉大学
南京鼓楼医院南京鼓楼医院
山东大学山东大学
深圳市第三人民医院深圳市第三人民医院
长海医院长海医院
河南省肿瘤医院河南省肿瘤医院
南方医科大学珠江医院南方医科大学珠江医院
南京大学南京大学
江苏省人民医院江苏省人民医院
重庆医科大学附属第一医院重庆医科大学附属第一医院
香港中文大学理工学院深圳综合科学与技术研究院香港中文大学理工学院深圳综合科学与技术研究院
中国航天员中心中国航天员中心
北京生命科学研究所北京生命科学研究所
中国科学院生物物理研究所中国科学院生物物理研究所
浙江大学浙江大学
中山大学中山大学
复旦大学复旦大学
上海交通大学上海交通大学
中国人民解放军军事科学院军事医学研究院中国人民解放军军事科学院军事医学研究院
北京大学北京大学
中国医学科学院血液病医院中国医学科学院血液病医院
苏州大学附属第一医院苏州大学附属第一医院
中国医学科学院皮肤病医院中国医学科学院皮肤病医院
浙江省人民医院浙江省人民医院
浙大妇产科医院浙大妇产科医院
浙大儿院浙大儿院
郑州大学第一附属医院郑州大学第一附属医院
深圳市人民医院深圳市人民医院
北京大学深圳医院北京大学深圳医院
广州市第一人民医院广州市第一人民医院
广东省中医院广东省中医院
广州市妇女儿童医疗中心广州市妇女儿童医疗中心
中山大学肿瘤防治中心中山大学肿瘤防治中心
上海市公共卫生临床中心上海市公共卫生临床中心
上海市红房子妇产科医院上海市红房子妇产科医院
上海市肺科医院上海市肺科医院
上海市第一人民医院上海市第一人民医院
北大肿瘤医院北大肿瘤医院
北京协和医院北京协和医院
华西医院华西医院
中国医学科学院肿瘤研究所中国医学科学院肿瘤研究所
瑞金医院瑞金医院
中山医院中山医院
华山医院华山医院
浙大一院浙大一院
浙大二院浙大二院
中山一院中山一院
北医三院北医三院
湘雅医院湘雅医院
同济医院同济医院
仁济医院仁济医院
西京医院西京医院
北大人民医院北大人民医院
湘雅二院湘雅二院
复旦大学附属肿瘤医院复旦大学附属肿瘤医院
301医院301医院
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